Human AKR1D1 Protein (Highly Pure)

<strong>Human AKR1D1 Protein (Highly Pure)</strong>_x000D_ <strong>Catalog number:</strong> B2011567_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 100 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 0.5 mg/mL_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -20 °C_x000D_ <strong>Keywords:</strong> AKR1D1 protein (His tag), Purified recombinant Human AKR1D1 protein, AKR1D1, AKRD-1 protein, Aldo-keto reductase family 1 protein, AKRD 1 protein, AKRD-1, member D1 protein, AKRD 1, CBAS2 protein, 3o5bred protein, SRD5B1 protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Appanna N, Gibson H, Gangitano E, Dempster NJ, Morris K, George S, Arvaniti A, Gathercole LL, Keevil B, Penning TM, Storbeck KH, Tomlinson JW, Nikolaou N. Differential activity and expression of human 5β-reductase (AKR1D1) splice variants J Mol Endocrinol. 2021 Mar;66(3):181-194._x000D_ 2: Penning TM. The aldo-keto reductases (AKRs): Overview Chem Biol Interact. 2015 Jun 5;234:236-46._x000D_ 3: Chen M, Penning TM. 5β-Reduced steroids and human Δ(4)-3-ketosteroid 5β-reductase (AKR1D1) Steroids. 2014 May;83:17-26._x000D_ 4: Nikolaou N, Gathercole LL, Kirkwood L, Dunford JE, Hughes BA, Gilligan LC, Oppermann U, Penning TM, Arlt W, Hodson L, Tomlinson JW. AKR1D1 regulates glucocorticoid availability and glucocorticoid receptor activation in human hepatoma cells J Steroid Biochem Mol Biol. 2019 May;189:218-227._x000D_ 5: Valanejad L, Nadolny C, Shiffka S, Chen Y, You S, Deng R. Differential Feedback Regulation of Δ4-3-Oxosteroid 5β-Reductase Expression by Bile Acids PLoS One. 2017 Jan 26;12(1):e0170960._x000D_ 6: Valanejad L, Ghareeb M, Shiffka S, Nadolny C, Chen Y, Guo L, Verma R, You S, Akhlaghi F, Deng R. Dysregulation of Δ(4)-3-oxosteroid 5β-reductase in diabetic patients: Implications and mechanisms Mol Cell Endocrinol. 2018 Jul 15;470:127-141._x000D_ 7: Chen M, Drury JE, Christianson DW, Penning TM. Conversion of human steroid 5β-reductase (AKR1D1) into 3β-hydroxysteroid dehydrogenase by single point mutation E120H: example of perfect enzyme engineering J Biol Chem. 2012 May 11;287(20):16609-22._x000D_ 8: Zhu P, Feng R, Lu X, Liao Y, Du Z, Zhai W, Chen K. Diagnostic and prognostic values of AKR1C3 and AKR1D1 in hepatocellular carcinoma Aging (Albany NY). 2021 Jan 20;13(3):4138-4156._x000D_ 9: Chen M, Wangtrakuldee P, Zang T, Duan L, Gathercole LL, Tomlinson JW, Penning TM. Human and murine steroid 5β-reductases (AKR1D1 and AKR1D4): insights into the role of the catalytic glutamic acid Chem Biol Interact. 2019 May 25;305:163-170._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/21255593">10: Chen M, Drury JE, Penning TM. Substrate specificity and inhibitor analyses of human steroid 5β-reductase (AKR1D1) Steroids. 2011 Apr;76(5):484-90. </a>_x000D_ _x000D_ <strong>Products Related to Human AKR1D1 Protein (Highly Pure) can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>