Anticancer agent 233

Anticancer agent 233 (compound 5g) is a 3,5-bis (arylmethylene) -4-piperidinone derivative with anticancer activity, with GI50 of 0.25 and 0.23 μM for cervical cancer (HeLa) and colon cancer (HCT116) cell lines, respectively. The chlorine atom on the aromatic ring of Anticancer agent 233 interacts well with the catalytic site of 20S proteasome, inhibiting the activity of 20S proteasome to exert its anticancer effect[1].

Product Specifications

CAS Number

9007-83-4

UNSPSC

12352005

Target

Proteasome

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/anticancer-agent-233.html

Smiles

O=C1/C(CN(C(CC2=CN=C(N)S2)=O)C/C1=C\C3=CC=C(Cl)C=C3Cl)=C\C4=CC=C(Cl)C=C4Cl

Molecular Formula

C24H17Cl4N3O2S

Molecular Weight

553.29

References & Citations

[1]Loori S, et al. Synthesis of novel aryl-substituted 2-aminopyridine derivatives by the cascade reaction of 1, 1-enediamines with vinamidinium salts to develop novel anti-Alzheimer agents[J]. Scientific Reports, 2024, 14 (1) : 13780.