17β-Hydroxywortmannin

17β-Hydroxywortmannin (Wortmannin-17β-ol) is an orally active inhibitor for phosphatidylinositol-3-kinase (PI-3-kinase) with an IC50 of 0.5 nM, suppresses the osteoclast resorption with an IC50 of 10 nM[1]. 17β-Hydroxywortmannin exhibits antitumor activity[2].

Product Specifications

CAS Number

[58053-83-1]

Product Name Alternative

Wortmannin-17β-ol

UNSPSC

12352005

Hazard Statement

H300+H310+H330

Target

PI3K

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer; Others

Assay Protocol

https://www.medchemexpress.com/17β-hydroxywortmannin.html

Solubility

10 mM in DMSO

Smiles

C[C@@]12C3=C(C(C4=C1C(C(O[C@@H]2COC)=O)=CO4)=O)[C@@]5([H])[C@](C[C@H]3OC(C)=O)([C@H](CC5)O)C

Molecular Formula

C23H26O8

Molecular Weight

430.45

Precautions

P260-P262-P264-P270-P271-P280-P284-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501

References & Citations

[1]Hall TJ, et al., Wortmannin, a potent inhibitor of phosphatidylinositol 3-kinase, inhibits osteoclastic bone resorption in vitro. Calcif Tissue Int. 1995 Apr;56 (4) :336-8.|[2]Zask A, et al., Synthesis and structure-activity relationships of ring-opened 17-hydroxywortmannins: potent phosphoinositide 3-kinase inhibitors with improved properties and anticancer efficacy. J Med Chem. 2008 Mar 13;51 (5) :1319-23.