INH1

INH1 specifically disrupts the Hec1/Nek2 interaction via direct Hec1 binding. INH1 shows promising cancer inhibition activity both in vitro and in vivo[1].

Product Specifications

CAS Number

[313553-47-8]

Product Name Alternative

IBT13131

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; NEKs

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/INH1.html

Purity

99.85

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=NC(C2=CC=C(C)C=C2C)=CS1)C3=CC=CC=C3

Molecular Formula

C18H16N2OS

Molecular Weight

308.40

Precautions

H302, H315, H319, H335

References & Citations

[1]Wu G, et al. Small molecule targeting the Hec1/Nek2 mitotic pathway suppresses tumor cell growth in culture and in animal. Cancer Res. 2008 Oct 15;68 (20) :8393-9.|[2]Shilong Zheng, et al. Discovery of a Series of Thiazole Derivatives as Novel Inhibitors of Metastatic Cancer Cell Migration and Invasion. ACS Med Chem Lett. 2013 Feb 14; 4 (2) : 191–196.|[3]Yongxia Zhu, et al. Small Molecule TH-39 Potentially Targets Hec1/Nek2 Interaction and Exhibits Antitumor Efficacy in K562 Cells via G0/G1 Cell Cycle Arrest and Apoptosis Induction. Cell Physiol Biochem. 2016;40 (1-2) :297-308.