KP-302

KP-302 (Compound 23) is a selective inhibitor of protein arginine deaminase PAD2 with a Ki of 60 μM. KP-302 also reverses physical disability in the EAE mouse model of multiple sclerosis (MS) and eliminates T cell infiltration in the brain. KP-302 can be studied in research as a disease-modifying agent for MS[1][2].

Product Specifications

CAS Number

[2082765-42-0]

UNSPSC

12352005

Target

Protein Arginine Deiminase

Type

Reference compound

Related Pathways

Epigenetics

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/kp-302.html

Concentration

10mM

Purity

99.78

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC=CN1C)N[C@H](C(NCC2=CC=CC=C2)=O)CCN3C=CN=C3

Molecular Formula

C20H23N5O2

Molecular Weight

365.43

References & Citations

[1]Sarswat A, et al. Inhibitors of protein arginine deiminases and their efficacy in animal models of multiple sclerosis. Bioorg Med Chem. 2017 May 1;25 (9) :2643-2656.|[2]Caprariello, A. V., et al., (2018) . Biochemically altered myelin triggers autoimmune demyelination. Proceedings of the National Academy of Sciences of the United States of America, 115 (21), 5528–5533.