TYM-3-98

TYM-3-98 is a selective inhibitor for PI3Kδ, with an IC50 of 7.1 nM. TYM-3-98 inhibits proliferationso of B-lymphoma cells. TYM-3-98 inhibits PI3K/AKT/mTOR signaling pathway through induction of apoptosis. TYM-3-98 exhibits good pahrmacokinetic characters and antitumor efficacy in mouse/rat model, without significant toxicity[1].

Product Specifications

CAS Number

[2820244-59-3]

UNSPSC

12352005

Target

Apoptosis; PI3K

Type

Reference compound

Related Pathways

Apoptosis; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/tym-3-98.html

Purity

98.9

Solubility

DMSO : 20 mg/mL (ultrasonic)

Smiles

COC1=C(F)C=C(C2=NN(C(C)C3=NN(C4=CC=CC(S(C)(=O)=O)=C4)C5=CC(Cl)=CC=C53)C6=C2C(N)=NC=N6)C=C1

Molecular Formula

C28H23ClFN7O3S

Molecular Weight

592.04

References & Citations

[1]Lou SY, et al., TYM-3-98, a novel selective inhibitor of PI3Kδ, demonstrates promising preclinical antitumor activity in B-cell lymphomas. Life Sci. 2024 Jun 15;347:122662.