KAR425
KAR425 is a potent and orally active antimalarial agent. KAR425 shows antimalarial activity against the Chloroquine-sensitive (CQS) D6, the Chloroquine-resistant (CQR) Dd2, and 7G8 strains of Plasmodium falciparum, with IC50 values of 62 nM, 55 nM, and 60 nM, respectively[1].
Product Specifications
CAS Number
1809050-49-4
UNSPSC
12352005
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/kar425.html
Smiles
CCC1=C(C)/C(N=C1C2=CC=CN2)=C\NC3CCCCCC3
Molecular Formula
C19H27N3
Molecular Weight
297.44
References & Citations
[1]Papireddy Kancharla, et al. Synthesis and Structure-Activity Relationships of Tambjamines and B-Ring Functionalized Prodiginines as Potent Antimalarials. J Med Chem. 2015 Sep 24;58 (18) :7286-309.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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