FLT3-ITD-IN-2
FLT3-ITD-IN-2 (Compound A1) is an inhibitor for FLT3-ITD kinase with an IC50 of 2.12 nM. FLT3-ITD-IN-2 inhibits the proliferation of FLT3-dependent human AML cell line MOLM-13 with an IC50 of 25.65 nM. FLT3-ITD-IN-2 exhibits antitumor efficacy against acute myeloid leukemia[1].
Product Specifications
UNSPSC
12352211
Target
FLT3
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/flt3-itd-in-2-7.html
Smiles
O=C([C@@]12[C@@H]3[C@@H]4[C@H]1[C@H]5[C@]4(C(OC)=O)[C@H]3[C@@H]25)N6CCN(C7CCN(C8=C(OC)C=C(NC9=C(C(N)=O)N=C(CC)C(NC%10CCOCC%10)=N9)C=C8)CC7)CC6
Molecular Formula
C39H50N8O6
Molecular Weight
726.86
References & Citations
[1]Chu D, et al., Identification of inhibitors targeting the FLT3-ITD mutation through 4D-QSAR, in vitro, and in silico. Eur J Med Chem. 2025 Jan 15;282:117089.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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