Clervonafusp alfa
Clervonafusp alfa (VAL-1221) is a fusion protein targeting both cytosolic and lysosomal glycogen. Clervonafusp alfa is comprised of the Fab portion of a cell-penetrating antibody and recombinant human acid alpha glucosidase (rhGAA), the former utilizing the nucleoside transporter ENT-2 to gain access to the cytosol, and the latter enters lysosomes via mannose-6-phosphate receptors (M6PRs) . Clervonafusp alfa can be used for late-onset Pompe disease research[1].
Product Specifications
CAS Number
2145123-44-8
Product Name Alternative
VAL-1221
UNSPSC
12352203
Target
Glycosidase
Type
Inhibitory Antibodies
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/clervonafusp-alfa.html
Solubility
H2O
Smiles
[Clervonafuspalfa]
References & Citations
[1]Kishnani P, et al. Safety and efficacy of VAL-1221, a novel fusion protein targeting cytoplasmic glycogen, in patients with late-onset Pompe disease. Molecular Genetics & Metabolism, 2019, 126 (2) :S85-S86.
Shipping Conditions
Room temperature
Scientific Category
Inhibitory Antibodies
Clinical Information
Phase 2
Frequently Asked Questions
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