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Ac- (d-Arg) -CEH- (d-Phe) -RWC-NH2

Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 is a cyclic octapeptide with MC4R agonism. Ac-DArg-c[Cys-Glu-His-DPhe-Arg-Trp-Cys]-NH 2 significantly increases heart rate and blood pressure[1].

Product Specifications

CAS Number

819048-44-7

UNSPSC

12352209

Target

Melanocortin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/ac-d-arg-ceh-d-phe-rwc-nh2.html

Purity

99.09

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

O=C([C@@H](NC([C@H](NC([C@@H](NC([C@@H](NC([C@H](CSSC[C@H](NC1=O)C(N)=O)NC([C@H](NC(C)=O)CCCNC(N)=N)=O)=O)CCC(O)=O)=O)CC2=CN=CN2)=O)CC3=CC=CC=C3)=O)CCCNC(N)=N)N[C@H]1CC4=CNC5=CC=CC=C45

Molecular Formula

C51H70N18O11S2

Molecular Weight

1175.35

References & Citations

[1]Doering SR, et al. Discovery of Nanomolar Melanocortin-3 Receptor (MC3R) -Selective Small Molecule Pyrrolidine Bis-Cyclic Guanidine Agonist Compounds Via a High-Throughput "Unbiased" Screening Campaign. J Med Chem. 2021 May 13;64 (9) :5577-5592. doi: 10.1021/acs.jmedchem.0c02041. Epub 2021 Apr 22. Erratum in: J Med Chem. 2023 May 25;66 (10) :7063-7065.

Shipping Conditions

Blue Ice

Storage Conditions

-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)

Scientific Category

Peptides

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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