Anti-Hu CD156c APC

CD156c is a type I transmembrane glycoprotein with a zinc-dependent metalloprotease activity. It serves as an endopeptidase of broad specificity, which is expressed mainly in thymus, liver, and muscles. Its expression can be induced in inflamed central nervous system, and in arthritic tissues. CD156c is involved in multiple sclerosis-associated myelin degradation. It also solubilizes various membrane proteins, including CD23, CD44, CD126, CD171, ephrin-A2, and other.

Product Specifications

Certification

RUO

Negative Species

Mouse

Reactivity

Human

Immunogen

Jurkat cells

Target Antigen

CD156c

Clone

11G2

Applications

FC (QC tested)

Format

APC

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Zola H et al.: Leukocyte and Stromal Cell Molecules, Wiley 2007, URL: , *Arduise C, Abache T, Li L, Billard M, Chabanon A, Ludwig A, Mauduit P, Boucheix C, Rubinstein E, Le Naour F: Tetraspanins regulate ADAM10-mediated cleavage of TNF-alpha and epidermal growth factor. J Immunol. 2008 Nov 15;181 (10) :7002-13., URL: https://pubmed.ncbi.nlm.nih.gov/18981120/, *Saint-Pol J, Billard M, Dornier E, Eschenbrenner E, Danglot L, Boucheix C, Charrin S, Rubinstein E: New insights into the tetraspanin Tspan5 using novel monoclonal antibodies. J Biol Chem. 2017 Jun 9;292 (23) :9551-9566., URL: https://pubmed.ncbi.nlm.nih.gov/28428248/

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody 11G2 recognizes an extracellular/luminal epitope of CD156c, a type I transmembrane glycoprotein, serving as a zinc-dependent metalloprotease.