Lasiocarpine (hydrochloride)
Lasiocarpine hydrochloride, a hepatotoxic pyrrolizidine alkaloid (PA), causes fatal liver veno-occlusive disease in vivo. Lasiocarpine hydrochloride is toxic only after its metabolic conversion to the toxic intermediate, including dehydrolasiocarpine and N-oxide[1].
Product Specifications
CAS Number
1976-49-4
UNSPSC
12352005
Target
Endogenous Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lasiocarpine-hydrochloride.html
Smiles
CO[C@H](C)[C@](C(C)(O)C)(O)C(OCC1=CCN2[C@@]1([H])[C@@H](OC(/C(C)=C\C)=O)CC2)=O.Cl
Molecular Formula
C21H34ClNO7
Molecular Weight
447.95
References & Citations
[1]Muluneh M Fashe, et al. Species-Specific Differences in the in Vitro Metabolism of Lasiocarpine. Chem Res Toxicol. 2015 Oct 19;28 (10) :2034-44.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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