4-IPP

4-IPP (4-Iodo-6-phenylpyrimidine) is a specific suicide substrate and irreversible inhibitor of macrophage migration inhibitory factor (MIF) [1].

Product Specifications

CAS Number

[41270-96-6]

Product Name Alternative

4-Iodo-6-phenylpyrimidine

UNSPSC

12352005

Hazard Statement

H302, H315, H318, H335

Target

Macrophage migration inhibitory factor (MIF)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/4-ipp.html

Purity

99.46

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

IC1=CC(C2=CC=CC=C2)=NC=N1

Molecular Formula

C10H7IN2

Molecular Weight

282.08

Precautions

H302, H315, H318, H335

References & Citations

[1]Zheng L, et al. Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP suppresses osteoclast formation and promotes osteoblast differentiation through the inhibition of the NF-κB signaling pathway. FASEB J. 2019 Jun;33 (6) :7667-7683.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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