4-IPP
4-IPP (4-Iodo-6-phenylpyrimidine) is a specific suicide substrate and irreversible inhibitor of macrophage migration inhibitory factor (MIF) [1].
Product Specifications
CAS Number
[41270-96-6]
Product Name Alternative
4-Iodo-6-phenylpyrimidine
UNSPSC
12352005
Hazard Statement
H302, H315, H318, H335
Target
Macrophage migration inhibitory factor (MIF)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/4-ipp.html
Purity
99.46
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
IC1=CC(C2=CC=CC=C2)=NC=N1
Molecular Formula
C10H7IN2
Molecular Weight
282.08
Precautions
H302, H315, H318, H335
References & Citations
[1]Zheng L, et al. Macrophage migration inhibitory factor (MIF) inhibitor 4-IPP suppresses osteoclast formation and promotes osteoblast differentiation through the inhibition of the NF-κB signaling pathway. FASEB J. 2019 Jun;33 (6) :7667-7683.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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