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HG-7-85-01-NH2

HG-7-85-01-NH2 is the HG-7-85-01 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER[1].

Product Specifications

CAS Number

1258391-29-5

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Bcr-Abl; Ligands for Target Protein for PROTAC; SNIPERs

Type

Reference compound

Related Pathways

PROTAC; Protein Tyrosine Kinase/RTK

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/hg-7-85-01-nh2.html

Purity

98.05

Solubility

DMSO : 125 mg/mL (ultrasonic; adjust pH to 5 with H2O)

Smiles

O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)C3=CC=CC(C4=CC=C5C(SC(N)=N5)=N4)=C3

Molecular Formula

C27H27F3N6OS

Molecular Weight

540.60

Precautions

H315, H319, H320

References & Citations

[1]Shibata N, et al. Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase. Sci Rep. 2018 Sep 10;8 (1) :13549.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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