HG-7-85-01-NH2
HG-7-85-01-NH2 is the HG-7-85-01 (ABL inhibitor) based moiety, binds to IAP ligand via a linker to form SNIPER[1].
Product Specifications
CAS Number
[1258391-29-5]
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Bcr-Abl; Ligands for Target Protein for PROTAC; SNIPERs
Type
Reference compound
Related Pathways
PROTAC; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hg-7-85-01-nh2.html
Purity
98.05
Solubility
DMSO : 125 mg/mL (ultrasonic; adjust pH to 5 with H2O)
Smiles
O=C(NC1=CC=C(CN2CCN(CC)CC2)C(C(F)(F)F)=C1)C3=CC=CC(C4=CC=C5C(SC(N)=N5)=N4)=C3
Molecular Formula
C27H27F3N6OS
Molecular Weight
540.60
Precautions
H315, H319, H320
References & Citations
[1]Shibata N, et al. Pharmacological difference between degrader and inhibitor against oncogenic BCR-ABL kinase. Sci Rep. 2018 Sep 10;8 (1) :13549.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
