Esmolol acid (hydrochloride)

Esmolol acid (ASL-8123) hydrochloride is a weak β-adrenergic receptor antagonist. Esmolol acid hydrochloride inhibits the heart rate and diastolic blood pressure response induced by Isoproterenol (HY-B0468) in a dose-dependent manner and can be used in studies of renal failure[1][2].

Product Specifications

CAS Number

[83356-60-9]

Product Name Alternative

ASL-8123 (hydrochloride)

UNSPSC

12352005

Hazard Statement

H319

Target

Adrenergic Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/esmolol-acid-hydrochloride.html

Smiles

O=C(CCC1=CC=C(C=C1)OCC(CNC(C)C)O)O.Cl

Molecular Formula

C15H24ClNO4

Molecular Weight

317.81

Precautions

P264-P280-P305+P351+P338

References & Citations

[1]J E Shaffer, et al. Beta-adrenoreceptor antagonist potency and pharmacodynamics of ASL-8123, the primary acid metabolite of esmolol. J Cardiovasc Pharmacol. 1988 Feb;11 (2) :187-92.|[2]J F Flaherty, et al. Pharmacokinetics of esmolol and ASL-8123 in renal failure. Clin Pharmacol Ther. 1989 Mar;45 (3) :321-7.