PHA-767491 (hydrochloride)

PHA-767491 hydrochloride is a dual Cdc7/Cdk9 inhibitor, with IC50s of 10 nM and 34 nM, respectively.

Product Specifications

CAS Number

[942425-68-5]

Product Name Alternative

CAY-10572 hydrochloride

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Apoptosis; CDK

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/PHA-767491-hydrochloride.html

Purity

99.49

Solubility

DMSO : 17.33 mg/mL (ultrasonic; warming) |H2O : 50 mg/mL (ultrasonic)

Smiles

O=C1C2=C(NC(C3=CC=NC=C3)=C2)CCN1.[H]Cl

Molecular Formula

C12H12ClN3O

Molecular Weight

249.70

Precautions

H302, H315, H319, H335

References & Citations

[1]Sasi NK, et al. The potent Cdc7-Dbf4 (DDK) kinase inhibitor XL413 has limited activity in many cancer cell lines and discovery of potential new DDK inhibitor scaffolds. PLoS One. 2014 Nov 20;9 (11) :e113300.|[2]Li W, et al. Dual Inhibition of Cdc7 and Cdk9 by PHA-767491 Suppresses Hepatocarcinoma Synergistically with 5-Fluorouracil. Curr Cancer Drug Targets. 2015;15 (3) :196-204.|[3]Erbayraktar Z, et al. Cell division cycle 7-kinase inhibitor PHA-767491 hydrochloride suppresses glioblastoma growth and invasiveness. Cancer Cell Int. 2016 Nov 18;16:88.|[4]Montagnoli A, et al. A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Nat Chem Biol. 2008 Jun;4 (6) :357-65.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK1; CDK2; CDK5; CDK9

Citation 01

Autophagy. 2022 Aug;18 (8) :1879-1897.|Sci Rep. 2021 Mar 8;11 (1) :5374.|Acta Pharmacol Sin. 2022 Apr;43 (4) :1033-1045.|Nat Commun. 2024 Dec 5;15 (1) :10594.