GPX4-IN-15

GPX4-IN-15 (Compound C1) is an inhibitor for GPX4, that inhibits 19.8% GPX4 at 1 μM. GPX4-IN-15 inhibits the proliferation of cancer cell MDA-MB-468, BT-549 and MDA-MB-231 with IC50 of 0.86, 0.96 and 0.48 μM[1].

Product Specifications

CAS Number

[3032966-42-7]

UNSPSC

12352005

Target

Glutathione Peroxidase

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/gpx4-in-15.html

Purity

98.79

Solubility

DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(OC)C1=CC=C(N(C(CCl)=O)C2=CC=C(OC)C(Cl)=C2)C=C1

Molecular Formula

C17H15Cl2NO4

Molecular Weight

368.21

References & Citations

[1]Chen T, et al., Discovery of Novel Potent Covalent Glutathione Peroxidase 4 Inhibitors as Highly Selective Ferroptosis Inducers for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2023 Jul 27;66 (14) :10036-10059.