TNF-α-IN-19

TNF-α-IN-19 is an inhibitor of TNFα that can block the interaction between TNFαRI, TRADD, and RIP1, the EC50 values for TNFα, IL-1β, and IL-1β/TNFα are 2.451, 3.792 and 1.54 μM, respectively. TNF-α-IN-19 only inhibits the degradation of IκBα when cells are stimulated by TNFα and not by IL-1β[1].

Product Specifications

CAS Number

[338773-13-0]

UNSPSC

12352005

Target

IKK; Interleukin Related; RIP kinase; TNF Receptor

Type

Reference compound

Related Pathways

Apoptosis; Immunology/Inflammation; NF-κB

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/tnf-α-in-19.html

Smiles

ClC1=CC=C(C2=NN=C3N2C4=C(N=C3C(F)(F)F)C=CC=C4)C=C1

Molecular Formula

C16H8ClF3N4

Molecular Weight

348.71

References & Citations

[1]Tarikere L. Gururaja, et al. A Class of SmallMolecules thatInhibit TNFa-Induced Survival and Death Pathways via Prevention of Interactions between TNFaRI, TRADD, and RIP1. Chemistry & Biology. 2007; 14 (10), 1105–1118.