Ixazomib-13C2,15N
Ixazomib-13C2,15N is 13C and 15N labeled Ixazomib. Ixazomib (MLN2238) is a selective, potent, and reversible proteasome inhibitor, which inhibits the chymotrypsin-like proteolytic (β5) site of the 20S proteasome with an IC50 of 3.4 nM (Ki of 0.93 nM) [1].
Product Specifications
UNSPSC
12352005
Target
Autophagy; Isotope-Labeled Compounds; Proteasome
Type
Isotope-Labeled Compounds
Related Pathways
Autophagy; Metabolic Enzyme/Protease; Others
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ixazomib-13c2-15n.html
Smiles
ClC1=CC(C([15N]([13C]([H])([13C](N[C@H](B(O)O)CC(C)C)=O)[H])[H])=O)=C(C=C1)Cl
Molecular Formula
C12 13C2H19BCl2N 15NO4
Molecular Weight
364.01
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Friedman JR, et al. Anticancer Activity of Natural and Synthetic Capsaicin Analogs. J Pharmacol Exp Ther. 2018 Mar;364 (3) :462-473.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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