Mitraphylline

Mitraphylline is the major pentacyclic oxindolic alkaloid presented in Uncaria tomentosa. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Mitraphylline exhibits antiproliferative activity in human glioma and neuroblastoma cell lines. Mitraphylline can inhibit interleukin release in vivo[1][2][3].

Product Specifications

CAS Number

[509-80-8]

UNSPSC

12352005

Hazard Statement

H300

Target

Interleukin Related; NF-κB

Type

Natural Products

Related Pathways

Immunology/Inflammation; NF-κB

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/mitraphylline.html

Purity

99.30

Solubility

DMSO : 6.76 mg/mL (ultrasonic)

Smiles

O=C1NC2=C([C@@]13CCN4C[C@@]5([C@@H](OC=C([C@]5(C[C@]43[H])[H])C(OC)=O)C)[H])C=CC=C2

Molecular Formula

C21H24N2O4

Molecular Weight

368.43

Precautions

H300

References & Citations

[1]Montserrat-de la Paz S, et al. Mitraphylline inhibits lipopolysaccharide-mediated activation of primary human neutrophils. Phytomedicine. 2016 Feb 15;23 (2) :141-8.|[2]Rojas-Duran, R., et al., (2012) . Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark. Journal of ethnopharmacology, 143 (3), 801–804.|[3]García Prado, E., et al., (2007) . Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines. Phytomedicine : international journal of phytotherapy and phytopharmacology, 14 (4), 280–284.