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Anti-Clostridium tetani Toxin Antibody

Mouse Monoclonal Antibody specific to Clostridium tetani Toxin

Product Specifications

CAS Number

9007-83-4

Product Name Alternative

Anti-Clostridium tetani Toxin Mouse Monoclonal Antibody

Gene Name

tetX

NCBI Gene ID

<a href="https://www.ncbi.nlm.nih.gov/gene/?term=tetX">tetX</a>

UniProt

P04958

Host

Mouse

Reactivity

Clostridium Tetani Toxin

Immunogen

Toxin purified from culture filtrate of C. tetani.

Target Antigen

Tetanus toxin

Target

Clostridium tetani Toxin

Clonality

Monoclonal

Isotype

IgG1

Type

Antibody

Applications

WB, ELISA, Neutralizing/Inhibition

Field of Research

Infectious Disease

Purification Method

Purified by immunoaffinity chromatography

Concentration

Lot Specific

Dilution

Dilute in PBS or medium that is identical to that used in the assay system.

Format

Purified

Form

Liquid

Buffer

Phosphate Buffered Saline

Function

Tetanus toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '76-Gln-|-Phe-77' bond of synaptobrevin-2.

Additionnal Information

ELISAImmunoblotting A band of ~150,000 is detected. <br><br>End users should determine optimal dilutions for their applications.

Storage Conditions

This antibody is stable at 4°C for short-term storage and for at least one (1) year at -20° to -70°C. Store product in appropriate aliquots to avoid multiple freeze-thaw cycles.

Specificity

This antibody recognizes C. tetani toxin.

Formulation

PBS, pH 7.4, 0.1% sodium azide.

Buffer pH

pH 7.4

Target Background

Clostridium tetani is an anaerobic, gram-positive, spore-forming rod found in soil and in the intestinal tracts and feces of animals. Most cases of tetanus result C. tetani spores entering small puncture wound. Infections remain localized, but systemic damage results from the production of exotoxins that are released when the spores germinate and grow. Tetanus toxin “Tetanospasmin†is one of the most potent toxins known, third only to botulinum toxin and diphtheria toxin. This potent neurotoxin enters peripheral nerves and travels to the central nervous system where it interferes with the release of neurotransmitters, causing muscle contraction and spasm.

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