UPGL00004
UPGL00004 is a potent allosteric glutaminase C (GAC) inhibitor (IC50=29 nM; Kd=27 nM) . UPGL00004 strongly inhibits the proliferation of highly aggressive triple-negative breast cancer cell lines[1].
Product Specifications
CAS Number
[1890169-95-5]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Glutaminase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/upgl00004.html
Concentration
10mM
Purity
98.0
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(NC1=NN=C(N2CCC(NC3=NN=C(NC(CC4=CC=CC=C4)=O)S3)CC2)S1)CC5=CC=CC=C5
Molecular Formula
C25H26N8O2S2
Molecular Weight
534.66
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Huang Q, et al. Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism. J Biol Chem. 2018 Mar 9;293 (10) :3535-3545.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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