BDM19
BDM19 binds and activates cytosolic BAX dimers, and prompts cell apoptosis either alone or in combination with BCL-2/BCL-XL inhibitor Navitoclax.
Product Specifications
CAS Number
500273-31-4
UNSPSC
12352005
Target
Apoptosis
Type
Reference compound
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bdm19.html
Purity
99.38
Solubility
10 mM in DMSO
Smiles
CC1=CC(/C=C/C2=NC3=CC=C(I)C=C3C(N2C4=CC=C(C(O)=O)C=C4)=O)=CC=C1
Molecular Formula
C24H17IN2O3
Molecular Weight
508.31
References & Citations
[1]Gitego N, et al. Chemical modulation of cytosolic BAX homodimer potentiates BAX activation and apoptosis. Nat Commun. 2023;14 (1) :8381. Published 2023 Dec 16.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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