Restrictocin

Restrictocin is a small endoribonuclease. Restrictocin cleaves one site in the conserved sarcin/ricin loop (SRL) in 23S-28S rRNA to disrupt GTPase activation when elongation factors bind to the ribosome, halt protein synthesis, and ultimately trigger apoptotic cell death[1].

Product Specifications

CAS Number

[1406-72-0]

UNSPSC

12352204

Hazard Statement

H302+H312+H332-H317-H334

Target

Apoptosis; Endonuclease

Type

Enzyme

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/restrictocin.html

Solubility

10 mM in DMSO

Smiles

[Restrictocin]

Precautions

P261-P264-P270-P271-P272-P280-P284-P302+P352-P304+P340-P330-P362+P364-P501

References & Citations

[1]Plantinga MJ, et al. The ribotoxin restrictocin recognizes its RNA substrate by selective engagement of active site residues. Biochemistry. 2011 Apr 12;50 (14) :3004-13.