Glasdegib-d4
Glasdegib-d4 (PF-04449913-d4) is deuterium labeled Glasdegib. Glasdegib (PF-04449913) is a potent and orally bioavailable smoothened inhibitor. Glasdegib (PF-04449913) binds to human SMO (amino acids 181-787) with an IC50 of 4 nM[1][2].
Product Specifications
Product Name Alternative
PF-04449913-d4
UNSPSC
12352005
Target
Isotope-Labeled Compounds; Smo
Type
Isotope-Labeled Compounds
Related Pathways
Others; Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
CN1[C@H](C[C@@H](CC1)NC(NC2=C([2H])C([2H])=C(C([2H])=C2[2H])C#N)=O)C3=NC4=CC=CC=C4N3
Molecular Formula
C21H18D4N6O
Molecular Weight
378.46
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Sadarangani A, et al. GLI2 inhibition abrogates human leukemia stem cell dormancy. J Transl Med. 2015 Mar 21;13:98.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported
Frequently Asked Questions
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