APT STAT3

APT STAT3 is a specific STAT3-binding peptide. APT STAT3 can bind STAT3 with high specificity and affinity (～231 nmol/L) . APT STAT3 is a tractable agent for translation to target the broad array of cancers harboring constitutively activated STAT3[1].

Product Specifications

CAS Number

[1345420-96-3]

UNSPSC

12352209

Target

STAT

Type

Peptides

Related Pathways

JAK/STAT Signaling; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/apt-stat3.html

Purity

99.38

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

C([C@@H](C(=O)N1[C@H](C(NCC(N[C@H](C(N[C@@H](CC=2C=3C(NC2)=CC=CC3)C(N[C@H](C(N[C@@H](CC=4C=5C(NC4)=CC=CC5)C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC=6C=7C(NC6)=CC=CC7)C(N[C@H](C(N[C@@H](CC=8C=9C(NC8)=CC=CC9)C(N[C@H](C(NCC(N[C@H](C(N[C@@H](CC%10=CC=C(O)C=C%10)C(N[C@H](C(N[C@@H](CC%11=CC=CC=C%11)C(N[C@H](C(N[C@@H](CCCCN)C(O)=O)=O)CC(C)C)=O)=O)CCC(N)=O)=O)=O)C)=O)=O)CCCCN)=O)=O)[C@@H](C)O)=O)=O)CCCCN)=O)=O)CC(N)=O)=O)CCC(O)=O)=O)=O)[C@@H](C)O)=O)=O)CO)=O)=O)CCC1)NC([C@@H](NC([C@H](CC%12=CC=CC=C%12)NC(CNC([C@H](CC%13=CN=CN%13)N)=O)=O)=O)CCC(N)=O)=O)C=%14C=%15C(NC%14)=CC=CC%15

Molecular Formula

C158H205N39O36

Molecular Weight

3226.56

References & Citations

[1]Kim D, et al. A specific STAT3-binding peptide exerts antiproliferative effects and antitumor activity by inhibiting STAT3 phosphorylation and signaling. Cancer Res. 2014 Apr 15;74 (8) :2144-51.