Dicer Rabbit Polyclonal Antibody
Dicer, also known as endoribonuclease Dicer or helicase with RNase motif, is an enzyme that in humans is encoded by the DICER1 gene. Being part of the RNase III family, Dicer cleaves double-stranded RNA (dsRNA) and pre-microRNA (pre-miRNA) into short double-stranded RNA fragments called small interfering RNA and microRNA, respectively. These fragments are approximately 20–25 base pairs long with a two-base overhang on the 3′-end. Dicer facilitates the activation of the RNA-induced silencing complex (RISC), which is essential for RNA interference. RISC has a catalytic component Argonaute, which is an endonuclease capable of degrading messenger RNA (mRNA).
Product Specifications
CAS Number
9007-83-4
Product Name Alternative
Abbreviation
DICER1, DICER, HERNA, KIAA0928
Swiss Prot
Q9UPY3 Human, Q8R418 Mouse
Cellular Locus
Cytoplasm, perinuclear region.
Host
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Recombinant protein within human aa 701-1,100 / 1,922.
Isotype
IgG
Conjugation
Non-conjugated
Type
Rabbit polyclonal Antibody
Applications
WB, IF-Cell, FC
Positive Control
MCF-7 cell lysate, 293 cell lysate, Daudi cell lysate, MCF-7, C2C12.
Concentration
2 mg/mL
Dilution
WB: 1:1,000;IF-Cell: 10ug/mL;FC: 1ug/mL
Purity
Immunogen affinity purified.
Form
Liquid
Buffer
PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight
Predicted band size: 218 kDa
Storage Conditions
Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.
Recombinant Antibody
No
Frequently Asked Questions
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