BAY-405
BAY-405 (compund 38) is a MAP4K1 inhibitor that exhibits nanomolar potency in biochemical and cellular assays and achieves in vivo exposure after oral administration[1].
Product Specifications
CAS Number
2442532-66-1
UNSPSC
12352005
Target
MAP4K
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bay-405.html
Smiles
FC(F)(C1(C2=CNC3=C2C(OC4=C(C=C(C=C4F)NC5=NCC6(CO5)CCOCC6)F)=CC=N3)CC1)F
Molecular Formula
C25H23F5N4O3
Molecular Weight
522.47
References & Citations
[1]Mowat J, et al. Discovery of BAY-405: An Azaindole-Based MAP4K1 Inhibitor for the Enhancement of T-Cell Immunity against Cancer. J Med Chem. 2024 Oct 10;67 (19) :17429-17453.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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