Esomeprazole

Esomeprazole ((S) -Omeprazole) is a potent and orally active proton pump inhibitor and reduces acid secretion through inhibition of the H+, K+-ATPase in gastric parietal cells. Esomeprazole has the potential for symptomatic gastroesophageal reflux disease research[1][2][3].

Product Specifications

CAS Number

[119141-88-7]

Product Name Alternative

(S) -Omeprazole; (-) -Omeprazole

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; Proton Pump

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Endocrinology; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/esomeprazole.html

Purity

99.46

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=[S@](C1=NC2=CC=C(OC)C=C2N1)CC3=NC=C(C)C(OC)=C3C

Molecular Formula

C17H19N3O3S

Molecular Weight

345.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Wayne Goh, et al. Use of proton pump inhibitors as adjunct treatment for triple-negative breast cancers. An introductory study. J Pharm Pharm Sci. 2014;17 (3) :439-46.|[2]Christina Nelson, et al. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017 Jan 26;8:16.|[3]Thomas J Johnson, et al. Esomeprazole: a clinical review. Am J Health Syst Pharm. 2002 Jul 15;59 (14) :1333-9.