(2R/S) -6-PNG
(2R/S) -6-PNG (6-Prenylnaringenin) is a potent and reversible Cav3.2 T-type Ca2+ channels (T-channels) blocker. (2R/S) -6-PNG can penetrate the blood-brain barrier (BBB) . (2R/S) -6-PNG suppresses neuropathic and visceral pain in mice[1].
Product Specifications
CAS Number
[68682-01-9]
Product Name Alternative
6-Prenylnaringenin; (±) -6-Prenylnaringenin
UNSPSC
12352005
Hazard Statement
H302+H312+H332
Target
Calcium Channel
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/2r-s-6-png.html
Purity
99.88
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C1CC(C2=CC=C(O)C=C2)OC3=CC(O)=C(C/C=C(C)\C)C(O)=C13
Molecular Formula
C20H20O5
Molecular Weight
340.37
Precautions
H302+H312+H332
References & Citations
[1]Fumiko Sekiguchi, et al. Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice. Neuropharmacology
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
T-type calcium channel
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