(2R/S) -6-PNG

(2R/S) -6-PNG (6-Prenylnaringenin) is a potent and reversible Cav3.2 T-type Ca2+ channels (T-channels) blocker. (2R/S) -6-PNG can penetrate the blood-brain barrier (BBB) . (2R/S) -6-PNG suppresses neuropathic and visceral pain in mice[1].

Product Specifications

CAS Number

[68682-01-9]

Product Name Alternative

6-Prenylnaringenin; (±) -6-Prenylnaringenin

UNSPSC

12352005

Hazard Statement

H302+H312+H332

Target

Calcium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/2r-s-6-png.html

Purity

99.88

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C1CC(C2=CC=C(O)C=C2)OC3=CC(O)=C(C/C=C(C)\C)C(O)=C13

Molecular Formula

C20H20O5

Molecular Weight

340.37

Precautions

H302+H312+H332

References & Citations

[1]Fumiko Sekiguchi, et al. Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice. Neuropharmacology