N2-iso-Butyryl-2'-O- (2-methoxyethyl) guanosine

N2-iso-Butyryl-2'-O- (2-methoxyethyl) guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7) [1].

Product Specifications

CAS Number

[440327-50-4]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Nucleoside Antimetabolite/Analog

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n2-iso-butyryl-2-o-2-methoxyethyl-guanosine.html

Solubility

10 mM in DMSO

Smiles

OC[C@@H]1[C@@H](O)[C@@H](OCCOC)[C@H](N2C=NC3=C2N=C(NC3=O)NC(C(C)C)=O)O1

Molecular Formula

C17H25N5O7

Molecular Weight

411.41

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Lee J, et al. Molecular basis for the immunostimulatory activity of guanine nucleoside analogs: activation of Toll-like receptor 7. Proc Natl Acad Sci U S A. 2003 May 27;100 (11) :6646-51.