AQ148
AQ148 is a HIV-1 protease inhibitor (Ki=137 nM) . The IC50 values of AQ148 for the inhibition of HIV-1, HIV-2 and SIV aspartic proteases are 1.5 μM, 3.4 μM and 5 μM, respectively[1].
Product Specifications
CAS Number
178820-70-7
UNSPSC
12352005
Target
HIV Protease
Type
Reference compound
Related Pathways
Anti-infection; Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/aq148.html
Smiles
C[N@+](CC1=CC=CC=C1)(C[C@H]([O-])C(NC(OC(C)(C)C)=O)CC2=CC=CC=C2)NC(C3=CC=CC=C3)=O
Molecular Formula
C30H37N3O4
Molecular Weight
503.63
References & Citations
[1]Rutenber, et al. "A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere." Bioorganic & medicinal chemistry 4.9 (1996) : 1545-1558.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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