S-23

S-23 is an orally active selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. S-23 induces androgen receptor (AR) -mediated transcriptional activation in CV-1 cells. S-23 increases prostate, seminal vesicle, and levator ani muscle weights in castrated rats[1][2].

Product Specifications

CAS Number

[1010396-29-8]

UNSPSC

12352005

Hazard Statement

H302, H413

Target

Androgen Receptor

Type

Reference compound

Related Pathways

Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/s-23.html

Purity

99.63

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(NC1=CC=C(C#N)C(C(F)(F)F)=C1)[C@@](C)(O)COC2=CC=C(Cl)C(F)=C2

Molecular Formula

C18H13ClF4N2O3

Molecular Weight

416.75

Precautions

H302, H413

References & Citations

[1]Jones A, et al. Preclinical characterization of a (S) -N- (4-cyano-3-trifluoromethyl-phenyl) -3- (3-fluoro, 4-chlorophenoxy) -2-hydroxy-2-methyl-propanamide: a selective androgen receptor modulator for hormonal male contraception. Endocrinology. 2009;150 (1) :385-395.|[2]Thevis M, et al. Characterization of in vitro generated metabolites of the selective androgen receptor modulators S-22 and S-23 and in vivo comparison to post-administration canine urine specimens. Drug Test Anal. 2010;2 (11-12) :589-598.