PROTAC GPX4 degrader-3
PROTAC GPX4 degrader-3 is a potent PROTAC GPX4 degrader with a DC50 (24h) of 0.019 μM and an IC50 of 0.024 μM in HT1080 cell[1].
Product Specifications
UNSPSC
12352005
Target
Ferroptosis; PROTACs
Type
Reference compound
Related Pathways
Apoptosis; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-gpx4-degrader-3.html
Smiles
O=C(OC)[C@@H](C1)N(C(CCl)=O)[C@@H](C2=CC=C(C(NCCCCCCCNC(CC3(C[C@@H](C4)C5)C[C@@H]5C[C@@H]4C3)=O)=O)C=C2)C6=C1C7=CC=CC=C7N6
Molecular Formula
C41H51ClN4O5
Molecular Weight
715.32
References & Citations
[1]Ning Y, et al. Design, synthesis, and biological evaluation of RSL3-based GPX4 degraders with hydrophobic tags. Eur J Med Chem. 2024 Jul 27;277:116719.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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