Hydrocortisone-d2

Hydrocortisone-d2 is the deuterium labeled Hydrocortisone. Hydrocortisone (Cortisol) is a steroid hormone or glucocorticoid secreted by the adrenal cortex[1][2].

Product Specifications

CAS Number

[1257650-73-9]

Product Name Alternative

Cortisol-d2

UNSPSC

12352211

Target

Endogenous Metabolite; Glucocorticoid Receptor; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease; Others; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Inflammation/Immunology

Purity

98.56

Solubility

10 mM in DMSO

Smiles

C[C@@]12[C@](CC[C@]2(O)C(CO)=O)([H])[C@@]3([H])[C@@]([C@H](C1)O)([H])[C@@]4(C(CC3)=CC(C([2H])C4[2H])=O)C

Molecular Formula

C21H28D2O5

Molecular Weight

364.47

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Bellinghausen I, et al. Inhibition of human allergic T-cell responses by IL-10-treated dendritic cells: differences from hydrocortisone-treated dendritic cells. J Allergy Clin Immunol. 2001 Aug;108 (2) :242-9.|[3]Chappell D, et al. Hydrocortisone preserves the vascular barrier by protecting the endothelial glycocalyx. Anesthesiology. 2007 Nov;107 (5) :776-84.|[4]Förster C, et al. Differential effects of hydrocortisone and TNFalpha on tight junction proteins in an in vitro model of the human blood-brain barrier. J Physiol. 2008 Apr 1;586 (7) :1937-49.