GRL-0496
Product Specifications
UNSPSC Description
GRL-0496 is a potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitor, with an IC50 of 30 nM in both enzyme inhibitory and antiviral assays. GRL-0496 shows SARS-CoV antiviral activity, with an EC50 of 6.9 μM[1].
Target Antigen
SARS-CoV
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/grl-0496.html
Smiles
O=C(C1=CC=CC2=C1C=CN2)OC3=CC(Cl)=CN=C3
Molecular Weight
272.69
References & Citations
[1]Ghosh AK, et, al. Design, synthesis and antiviral efficacy of a series of potent chloropyridyl ester-derived SARS-CoV 3CLpro inhibitors. Bioorg Med Chem Lett. 2008 Oct 15;18(20):5684-8.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-137954/GRL-0496-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-137954/GRL-0496-SDS-MedChemExpress.pdf
CAS Number
1087243-14-8
Available Sizes
Curated Selection
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