EB-42486
Product Specifications
UNSPSC Description
EB-42486 is a novel, potent, and highly selective G2019S-LRRK2 inhibitor (IC50 < 0.2 nM).
Target Antigen
LRRK2
Type
Reference compound
Related Pathways
Autophagy
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/eb-42486.html
Solubility
DMSO : 125 mg/mL (ultrasonic)
Smiles
O=C(C1=C(C)N(C)C2=NN=NN2C1(C)C)NC3=CC4=C(NN=C4C5=CC=CC=C5)C=C3
Molecular Weight
414.46
References & Citations
[1]Garofalo AW, et al. Selective Inhibitors of G2019S-LRRK2 Kinase Activity. J Med Chem. 2020 Dec 10;63(23):14821-14839.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-142647/EB-42486-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-142647/EB-42486-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
2390475-81-5
Available Sizes
Curated Selection
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