EB-42486

EB-42486 is a novel, potent, and highly selective G2019S-LRRK2 inhibitor (IC50: [1][2].

Product Specifications

CAS Number

[2390475-81-5]

UNSPSC

12352005

Hazard Statement

H228, H315, H319

Target

LRRK2

Type

Reference compound

Related Pathways

Autophagy

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/eb-42486.html

Purity

99.62

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

O=C(C1=C(C)N(C)C2=NN=NN2C1(C)C)NC3=CC4=C(NN=C4C5=CC=CC=C5)C=C3

Molecular Formula

C22H22N8O

Molecular Weight

414.46

Precautions

H228, H315, H319

References & Citations

[1]Garofalo AW, et al. Selective Inhibitors of G2019S-LRRK2 Kinase Activity. J Med Chem. 2020 Dec 10;63 (23) :14821-14839. |[2]Thakur G, et al. Structural Insights and Development of LRRK2 Inhibitors for Parkinson's Disease in the Last Decade. Genes (Basel) . 2022 Aug 11;13 (8) :1426.