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QDPR-IN-1

QDPR-IN-1 (Compound 9b) is a potent QDPR inhibitor with an IC50 of 0.72 μM[1].

Product Specifications

CAS Number

29415-71-2

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Dihydrofolate reductase (DHFR)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/qdpr-in-1.html

Purity

99.28

Solubility

DMSO : 3.12 mg/mL (ultrasonic; adjust pH to 4 with 1 M HCl)

Smiles

O=C1NNC(C2=CC(N(CC)CC)=CC=C12)=O

Molecular Formula

C12H15N3O2

Molecular Weight

233.27

Precautions

H302, H315, H319, H335

References & Citations

[1]Hara S, et al. Inhibition of QDPR synergistically modulates intracellular tetrahydrobiopterin profiles in cooperation with methotrexate. Biochem Biophys Res Commun. 2024 Jul 12;717:150059.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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