QDPR-IN-1
QDPR-IN-1 (Compound 9b) is a potent QDPR inhibitor with an IC50 of 0.72 μM[1].
Product Specifications
CAS Number
[29415-71-2]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Dihydrofolate reductase (DHFR)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/qdpr-in-1.html
Purity
99.28
Solubility
DMSO : 3.12 mg/mL (ultrasonic; adjust pH to 4 with 1 M HCl)
Smiles
O=C1NNC(C2=CC(N(CC)CC)=CC=C12)=O
Molecular Formula
C12H15N3O2
Molecular Weight
233.27
Precautions
H302, H315, H319, H335
References & Citations
[1]Hara S, et al. Inhibition of QDPR synergistically modulates intracellular tetrahydrobiopterin profiles in cooperation with methotrexate. Biochem Biophys Res Commun. 2024 Jul 12;717:150059.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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