RIG-I Helicase Domain Human Recombinant

<strong>RIG-I Helicase Domain Human Recombinant</strong>_x000D_ <strong>Catalog number:</strong> B2017445_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Amount:</strong> 50 µg_x000D_ <strong>Molecular Weight or Concentration:</strong> 66.47 kDa_x000D_ <strong>Supplied as:</strong> Solution_x000D_ <strong>Applications:</strong> a molecular tool for various biochemical applications_x000D_ <strong>Storage:</strong> -80°C_x000D_ <strong>Keywords:</strong> DEAD Box Protein 58, Probable ATP-dependent RNA Helicase DDX58, Retinoic Acid-inducible Gene 1 Protein_x000D_ <strong>Grade:</strong> Biotechnology grade. All products are highly pure. All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Zhao J, Zeng Y, Xu S, Chen J, Shen G, Yu C, Knipe D, Yuan W, Peng J, Xu W, Zhang C, Xia Z, Feng P. A Viral Deamidase Targets the Helicase Domain of RIG-I to Block RNA-Induced Activation Cell Host Microbe. 2016 Dec 14;20(6):770-784._x000D_ 2: Yoneyama M, Onomoto K, Fujita T. Cytoplasmic recognition of RNA Adv Drug Deliv Rev. 2008 Apr 29;60(7):841-6._x000D_ 3: Kageyama M, Takahasi K, Narita R, Hirai R, Yoneyama M, Kato H, Fujita T. 55 Amino acid linker between helicase and carboxyl terminal domains of RIG-I functions as a critical repression domain and determines inter-domain conformation Biochem Biophys Res Commun. 2011 Nov 11;415(1):75-81._x000D_ 4: Oshiumi H, Sakai K, Matsumoto M, Seya T. DEAD/H BOX 3 (DDX3) helicase binds the RIG-I adaptor IPS-1 to up-regulate IFN-beta-inducing potential Eur J Immunol. 2010 Apr;40(4):940-8._x000D_ 5: Sanchez David RY, Combredet C, Najburg V, Millot GA, Beauclair G, Schwikowski B, Léger T, Camadro JM, Jacob Y, Bellalou J, Jouvenet N, Tangy F, Komarova AV. LGP2 binds to PACT to regulate RIG-I- and MDA5-mediated antiviral responses Sci Signal. 2019 Oct 1;12(601):eaar3993._x000D_ 6: Gee P, Chua PK, Gevorkyan J, Klumpp K, Najera I, Swinney DC, Deval J. Essential role of the N-terminal domain in the regulation of RIG-I ATPase activity J Biol Chem. 2008 Apr 4;283(14):9488-96._x000D_ 7: Sun Y, Ding N, Ding SS, Yu S, Meng C, Chen H, Qiu X, Zhang S, Yu Y, Zhan Y, Ding C. Goose RIG-I functions in innate immunity against Newcastle disease virus infections Mol Immunol. 2013 Apr;53(4):321-7._x000D_ 8: Vaughn LS, Chukwurah E, Patel RC. Opposite actions of two dsRNA-binding proteins PACT and TRBP on RIG-I mediated signaling Biochem J. 2021 Feb 12;478(3):493-510._x000D_ 9: Zheng J, Wang C, Chang MR, Devarkar SC, Schweibenz B, Crynen GC, Garcia-Ordonez RD, Pascal BD, Novick SJ, Patel SS, Marcotrigiano J, Griffin PR. HDX-MS reveals dysregulated checkpoints that compromise discrimination against self RNA during RIG-I mediated autoimmunity Nat Commun. 2018 Dec 18;9(1):5366._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/33941659">10: Cai H, Liu X, Zhang F, Han QY, Liu ZS, Xue W, Guo ZL, Zhao JM, Sun LM, Wang N, Mao J, He K, Xia T, Chen Y, Chen L, Li AL, Zhou T, Zhang XM, Li WH, Li T. G3BP1 Inhibition Alleviates Intracellular Nucleic Acid-Induced Autoimmune Responses J Immunol. 2021 May 15;206(10):2453-2467. </a>_x000D_ _x000D_ <strong>Products Related to RIG-I Helicase Domain Human Recombinant can be found at</strong> <a href="https://moleculardepot.com/product-category/Proteins/"> Proteins</a>