P, p'-DDE-d8

P, p'-DDE-d8 is the deuterium labeled p, p'-DDE[1]. p, p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[2].

Product Specifications

CAS Number

[93952-19-3]

Product Name Alternative

4,4'-DDE-d8; p, p'-Dichlorodiphenyldichloroethylene-d8

UNSPSC

12352005

Target

Androgen Receptor; Drug Metabolite

Type

Isotope-Labeled Compounds

Related Pathways

Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Purity

Solubility

10 mM in DMSO

Smiles

Cl/C(Cl)=C(C1=C([2H])C([2H])=C(C([2H])=C1[2H])Cl)/C2=C([2H])C([2H])=C(C([2H])=C2[2H])Cl

Molecular Formula

C14D8Cl4

Molecular Weight

326.07

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Kelce WR, et al. Persistent DDT metabolite p, p'-DDE is a potent androgen receptor antagonist. Nature. 1995;375 (6532) :581-585.