Pim1/AKK1-IN-1
Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK.
Product Specifications
CAS Number
[1093222-27-5]
Product Name Alternative
LKB1/AAK1 dual inhibitor
UNSPSC
12352005
Hazard Statement
H315, H319
Target
Pim
Type
Reference compound
Related Pathways
JAK/STAT Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Pim1-AKK1-IN-1.html
Purity
98.40
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
N#CC1=CC=C(C2=CN=C3C(C(NC(C4=CC=CN=C4)=O)=CN3)=C2)C=C1
Molecular Formula
C20H13N5O
Molecular Weight
339.35
Precautions
H315, H319
References & Citations
[1]Bamborough P, et al. Assessment of chemical coverage of kinome space and its implications for kinase drug discovery. J Med Chem. 2008 Dec 25;51 (24) :7898-914.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PIM1
Available Sizes
Curated Selection
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