Traxoprodil (mesylate)
Traxoprodil mesylate (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM.
Product Specifications
CAS Number
188591-67-5
Product Name Alternative
CP101,606 (mesylate)
UNSPSC
12352005
Hazard Statement
H301-H319-H400
Target
IGluR
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/traxoprodil-mesylate.html
Solubility
10 mM in DMSO
Smiles
CS(=O)(O)=O.OC1(C2=CC=CC=C2)CCN(CC1)[C@@H](C)[C@H](C3=CC=C(C=C3)O)O
Molecular Formula
C21H29NO6S
Molecular Weight
423.52
Precautions
P264-P270-P273-P280-P330-P391-P405-P501
References & Citations
[1]Chenard BL, et al. (1S,2S) -1- (4-hydroxyphenyl) -2- (4-hydroxy-4-phenylpiperidino) -1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J Med Chem. 1995 Aug 4;38 (16) :3138-45.|[2]Poleszak E, et al. Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice. Metab Brain Dis. 2016 Aug;31 (4) :803-14.|[3]Naspolini AP, et al. Traxoprodil decreases pentylenetetrazol-induced seizures. Epilepsy Res. 2012 Jun;100 (1-2) :12-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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