Traxoprodil (mesylate)

Traxoprodil mesylate (CP101,606) is a potent and selective NMDA antagonist and protect hippocampal neurons with an IC50 of 10 nM.

Product Specifications

CAS Number

[188591-67-5]

Product Name Alternative

CP101,606 (mesylate)

UNSPSC

12352005

Hazard Statement

H301-H319-H400

Target

IGluR

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/traxoprodil-mesylate.html

Solubility

10 mM in DMSO

Smiles

CS(=O)(O)=O.OC1(C2=CC=CC=C2)CCN(CC1)[C@@H](C)[C@H](C3=CC=C(C=C3)O)O

Molecular Formula

C21H29NO6S

Molecular Weight

423.52

Precautions

P264-P270-P273-P280-P330-P391-P405-P501

References & Citations

[1]Chenard BL, et al. (1S,2S) -1- (4-hydroxyphenyl) -2- (4-hydroxy-4-phenylpiperidino) -1-propanol: a potent new neuroprotectant which blocks N-methyl-D-aspartate responses. J Med Chem. 1995 Aug 4;38 (16) :3138-45.|[2]Poleszak E, et al. Traxoprodil, a selective antagonist of the NR2B subunit of the NMDA receptor, potentiates the antidepressant-like effects of certain antidepressant drugs in the forced swim test in mice. Metab Brain Dis. 2016 Aug;31 (4) :803-14.|[3]Naspolini AP, et al. Traxoprodil decreases pentylenetetrazol-induced seizures. Epilepsy Res. 2012 Jun;100 (1-2) :12-9.