1Z105

1Z105 is an oral active TLR4/MD2 ligand. 1Z105 enhances dendritic cell maturation and antigen presentation and prevents rthritis[1][2].

Product Specifications

CAS Number

[1438280-73-9]

UNSPSC

12352005

Target

Toll-like Receptor (TLR)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/1z105.html

Smiles

O=C1C2=C(C3=C(N2C)C=CC=C3)N=C(N1C4=CC=CC=C4)SCC(NC5CCCCC5)=O

Molecular Formula

C25H26N4O2S

Molecular Weight

446.56

References & Citations

[1]Goff PH, et al. Synthetic Toll-like receptor 4 (TLR4) and TLR7 ligands as influenza virus vaccine adjuvants induce rapid, sustained, and broadly protective responses. J Virol. 2015;89 (6) :3221-3235.|[2]Hayashi T, et al. Novel synthetic toll-like receptor 4/MD2 ligands attenuate sterile inflammation. J Pharmacol Exp Ther. 2014;350 (2) :330-340.