Anti-MRSA agent 18
Anti-MRSA agent 18 (E17) is an inhibitor of MRSA with MIC values of 2 μg/mL for S. aureus and 4 μg/mL for MRSA, respectively. Anti-MRSA agent 18 interacts with bacterial cell membrane phosphatidylglycerol and cardiolipin, causing changes in cell membrane permeability and polarization, increased intracellular ROS, and DNA and protein leakage, thereby accelerating bacterial death[1].
Product Specifications
CAS Number
9007-83-4
UNSPSC
12352005
Target
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/anti-mrsa-agent-18.html
Smiles
C=CCC1=C(C=CC(C2=C3OC(C4=C(C=CC=C4Cl)Cl)=NC3=CC(CC=C)=C2)=C1)OCCC[N+](C)(CC(NCCCC)=O)C.[Br-]
Molecular Formula
C36H42BrCl2N3O3
Molecular Weight
715.55
References & Citations
[1]Yang R, et al. Membrane-Targeting Amphiphilic Honokiol Derivatives Containing an Oxazole Moiety as Potential Antibacterials against Methicillin-Resistant Staphylococcus aureus. J Med Chem. 2024 Sep 26;67 (18) :16858-16872.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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