Centrinone-B

Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor, with a Ki of 0.59 nM.

Product Specifications

CAS Number

[1798871-31-4]

Product Name Alternative

LCR-323

UNSPSC

12352005

Hazard Statement

H302

Target

Polo-like Kinase (PLK)

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Centrinone-B.html

Purity

98.65

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

FC(C([N+]([O-])=O)=CC=C1)=C1CS(C2=CC(F)=C(SC3=NC(NC4=NNC(C)=C4)=C(OC)C(N5CCCCC5)=N3)C=C2)(=O)=O

Molecular Formula

C27H27F2N7O5S2

Molecular Weight

631.67

Precautions

H302

References & Citations

[1]Wong YL, et al. Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science. 2015 Jun 5;348 (6239) :1155-60.|[2]Denu RA, et al. Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma. Mol Cancer Res. 2018 Jan 12.