Centrinone-B
Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor, with a Ki of 0.59 nM.
Product Specifications
CAS Number
1798871-31-4
Product Name Alternative
LCR-323
UNSPSC
12352005
Hazard Statement
H302
Target
Polo-like Kinase (PLK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/Centrinone-B.html
Purity
98.65
Solubility
DMSO : 25 mg/mL (ultrasonic)
Smiles
FC(C([N+]([O-])=O)=CC=C1)=C1CS(C2=CC(F)=C(SC3=NC(NC4=NNC(C)=C4)=C(OC)C(N5CCCCC5)=N3)C=C2)(=O)=O
Molecular Formula
C27H27F2N7O5S2
Molecular Weight
631.67
Precautions
H302
References & Citations
[1]Wong YL, et al. Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science. 2015 Jun 5;348 (6239) :1155-60.|[2]Denu RA, et al. Centriole Overduplication is the Predominant Mechanism Leading to Centrosome Amplification in Melanoma. Mol Cancer Res. 2018 Jan 12.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PLK4
Available Sizes
Frequently Asked Questions
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